Hello, have you gotten any resolution to this? I am experiencing the same thing.

Hello, I have attached a schematic of a board design using an ESP32-WROOM-32U module that, after being powered on for about five days, stops functioning and becomes completely unresponsive. No output from serial at boot. Measuring voltage at the EN pin over the five days shows a slow drop in voltage...

Hello, sorry to revive an old thread. I am having this same issue on a couple of custom boards. Did you ever resolve this issue?

Thank you for any advise.